{
  "schemaVersion": "1.0.0",
  "asOf": "2026-10-27",
  "coverageNote": "Manually reviewed starting catalog. Absence of a mission or evidence axis means it has not been catalogued; it is not evidence that no such research exists.",
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    {
      "id": "clay-index",
      "title": "Millennium Prize Problems",
      "url": "https://www.claymath.org/millennium-problems/",
      "publisher": "Clay Mathematics Institute",
      "kind": "institutional_reference",
      "reviewedAt": "2026-10-27"
    },
    {
      "id": "clay-rules",
      "title": "Rules for the Millennium Prize Problems",
      "url": "https://www.claymath.org/millennium-problems/rules/",
      "publisher": "Clay Mathematics Institute",
      "kind": "institutional_reference",
      "reviewedAt": "2026-10-27"
    },
    {
      "id": "clay-birch",
      "title": "Birch and Swinnerton-Dyer Conjecture",
      "url": "https://www.claymath.org/millennium/birch-and-swinnerton-dyer-conjecture/",
      "publisher": "Clay Mathematics Institute",
      "kind": "institutional_reference",
      "reviewedAt": "2026-10-27"
    },
    {
      "id": "clay-hodge",
      "title": "Hodge Conjecture",
      "url": "https://www.claymath.org/millennium/hodge-conjecture/",
      "publisher": "Clay Mathematics Institute",
      "kind": "institutional_reference",
      "reviewedAt": "2026-10-27"
    },
    {
      "id": "clay-navier",
      "title": "Navier–Stokes Equation",
      "url": "https://www.claymath.org/millennium/navier-stokes-equation/",
      "publisher": "Clay Mathematics Institute",
      "kind": "institutional_reference",
      "reviewedAt": "2026-10-27"
    },
    {
      "id": "clay-pnp",
      "title": "P vs NP",
      "url": "https://www.claymath.org/millennium/p-vs-np/",
      "publisher": "Clay Mathematics Institute",
      "kind": "institutional_reference",
      "reviewedAt": "2026-10-27"
    },
    {
      "id": "clay-poincare",
      "title": "Poincaré Conjecture",
      "url": "https://www.claymath.org/millennium/poincare-conjecture/",
      "publisher": "Clay Mathematics Institute",
      "kind": "institutional_reference",
      "reviewedAt": "2026-10-27"
    },
    {
      "id": "clay-riemann",
      "title": "Riemann Hypothesis",
      "url": "https://www.claymath.org/millennium/riemann-hypothesis/",
      "publisher": "Clay Mathematics Institute",
      "kind": "institutional_reference",
      "reviewedAt": "2026-10-27"
    },
    {
      "id": "clay-yang",
      "title": "Yang–Mills & the Mass Gap",
      "url": "https://www.claymath.org/millennium/yang-mills-the-maths-gap/",
      "publisher": "Clay Mathematics Institute",
      "kind": "institutional_reference",
      "reviewedAt": "2026-10-27"
    },
    {
      "id": "alpha-blog",
      "title": "AlphaEvolve: a Gemini-powered coding agent",
      "url": "https://deepmind.google/blog/alphaevolve-a-gemini-powered-coding-agent-for-designing-advanced-algorithms/",
      "publisher": "Google DeepMind",
      "kind": "researcher_announcement",
      "reviewedAt": "2026-10-27"
    },
    {
      "id": "alpha-paper",
      "title": "AlphaEvolve: A coding agent for scientific and algorithmic discovery (v1)",
      "url": "https://arxiv.org/abs/2506.13131v1",
      "publisher": "Novikov et al. / arXiv",
      "kind": "preprint",
      "reviewedAt": "2026-10-27"
    },
    {
      "id": "tcv-paper",
      "title": "Magnetic control of tokamak plasmas through deep reinforcement learning",
      "url": "https://www.nature.com/articles/s41586-021-04301-9",
      "publisher": "Degrave et al. / Nature",
      "kind": "peer_reviewed_paper",
      "reviewedAt": "2026-10-27"
    },
    {
      "id": "ipf-paper",
      "title": "A generative AI-discovered TNIK inhibitor for idiopathic pulmonary fibrosis: a randomized phase 2a trial",
      "url": "https://www.nature.com/articles/s41591-025-03743-2",
      "publisher": "Xu et al. / Nature Medicine",
      "kind": "peer_reviewed_paper",
      "reviewedAt": "2026-10-27"
    }
  ],
  "problems": [
    {
      "id": "riemann",
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      "fields": [
        "Math"
      ],
      "specialty": "Number theory",
      "diseases": [],
      "collection": "Millennium Prize Problems",
      "summary": "A statement about the nontrivial zeros of the zeta function and the distribution of prime numbers.",
      "origin": {
        "date": "1859",
        "precision": "year",
        "eventType": "formulated",
        "note": "Formulated in Riemann’s 1859 paper.",
        "sourceIds": [
          "clay-riemann"
        ]
      },
      "historyEnd": null,
      "status": {
        "state": "open",
        "authorityLabel": "Unsolved",
        "basis": "Clay Mathematics Institute classification, reviewed 2026-10-27.",
        "sourceIds": [
          "clay-riemann"
        ]
      },
      "milestones": [
        {
          "date": "2000-05-24",
          "precision": "day",
          "eventType": "named",
          "note": "Included in the Millennium Prize Problems; this is not the original formulation date.",
          "sourceIds": [
            "clay-index"
          ]
        }
      ],
      "sourceIds": [
        "clay-riemann",
        "clay-index"
      ],
      "reviewedAt": "2026-10-27"
    },
    {
      "id": "pnp",
      "title": "P vs NP",
      "fields": [
        "Computer Science",
        "Math"
      ],
      "specialty": "Computational complexity",
      "diseases": [],
      "collection": "Millennium Prize Problems",
      "summary": "Can every problem whose answer can be checked efficiently also be solved efficiently?",
      "origin": {
        "date": "1971",
        "precision": "year",
        "eventType": "formulated",
        "note": "Clay dates the independent formulation by Cook and Levin to 1971.",
        "sourceIds": [
          "clay-pnp"
        ]
      },
      "historyEnd": null,
      "status": {
        "state": "open",
        "authorityLabel": "Unsolved",
        "basis": "Clay Mathematics Institute classification, reviewed 2026-10-27.",
        "sourceIds": [
          "clay-pnp"
        ]
      },
      "milestones": [
        {
          "date": "2000-05-24",
          "precision": "day",
          "eventType": "named",
          "note": "Included in the Millennium Prize Problems; this is not the original formulation date.",
          "sourceIds": [
            "clay-index"
          ]
        }
      ],
      "sourceIds": [
        "clay-pnp",
        "clay-index"
      ],
      "reviewedAt": "2026-10-27"
    },
    {
      "id": "navier",
      "title": "Navier–Stokes existence & smoothness",
      "fields": [
        "Math",
        "Physics"
      ],
      "specialty": "Fluid dynamics",
      "diseases": [],
      "collection": "Millennium Prize Problems",
      "summary": "Establish the existence and smoothness of solutions, or an appropriate breakdown, for the specified three-dimensional fluid equations.",
      "origin": null,
      "historyEnd": null,
      "status": {
        "state": "open",
        "authorityLabel": "Active",
        "basis": "Clay Mathematics Institute classification, reviewed 2026-10-27.",
        "sourceIds": [
          "clay-navier"
        ]
      },
      "milestones": [
        {
          "date": "2000-05-24",
          "precision": "day",
          "eventType": "named",
          "note": "Included in the Millennium Prize Problems; this is not the original formulation date.",
          "sourceIds": [
            "clay-index"
          ]
        }
      ],
      "sourceIds": [
        "clay-navier",
        "clay-index"
      ],
      "reviewedAt": "2026-10-27"
    },
    {
      "id": "birch",
      "title": "Birch and Swinnerton-Dyer Conjecture",
      "fields": [
        "Math"
      ],
      "specialty": "Number theory",
      "diseases": [],
      "collection": "Millennium Prize Problems",
      "summary": "Relate rational points on elliptic curves to the behavior of an associated L-function.",
      "origin": null,
      "historyEnd": null,
      "status": {
        "state": "open",
        "authorityLabel": "Unsolved",
        "basis": "Clay Mathematics Institute classification, reviewed 2026-10-27.",
        "sourceIds": [
          "clay-birch"
        ]
      },
      "milestones": [
        {
          "date": "2000-05-24",
          "precision": "day",
          "eventType": "named",
          "note": "Included in the Millennium Prize Problems; this is not the original formulation date.",
          "sourceIds": [
            "clay-index"
          ]
        }
      ],
      "sourceIds": [
        "clay-birch",
        "clay-index"
      ],
      "reviewedAt": "2026-10-27"
    },
    {
      "id": "hodge",
      "title": "Hodge Conjecture",
      "fields": [
        "Math"
      ],
      "specialty": "Algebraic geometry",
      "diseases": [],
      "collection": "Millennium Prize Problems",
      "summary": "Determine which cohomology classes of complex projective varieties arise from algebraic cycles.",
      "origin": null,
      "historyEnd": null,
      "status": {
        "state": "open",
        "authorityLabel": "Unsolved",
        "basis": "Clay Mathematics Institute classification, reviewed 2026-10-27.",
        "sourceIds": [
          "clay-hodge"
        ]
      },
      "milestones": [
        {
          "date": "2000-05-24",
          "precision": "day",
          "eventType": "named",
          "note": "Included in the Millennium Prize Problems; this is not the original formulation date.",
          "sourceIds": [
            "clay-index"
          ]
        }
      ],
      "sourceIds": [
        "clay-hodge",
        "clay-index"
      ],
      "reviewedAt": "2026-10-27"
    },
    {
      "id": "yang",
      "title": "Yang–Mills existence & mass gap",
      "fields": [
        "Physics",
        "Math"
      ],
      "specialty": "Quantum field theory",
      "diseases": [],
      "collection": "Millennium Prize Problems",
      "summary": "Construct a rigorous quantum Yang–Mills theory in four dimensions and establish a positive mass gap.",
      "origin": null,
      "historyEnd": null,
      "status": {
        "state": "open",
        "authorityLabel": "Unsolved",
        "basis": "Clay Mathematics Institute classification, reviewed 2026-10-27.",
        "sourceIds": [
          "clay-yang"
        ]
      },
      "milestones": [
        {
          "date": "2000-05-24",
          "precision": "day",
          "eventType": "named",
          "note": "Included in the Millennium Prize Problems; this is not the original formulation date.",
          "sourceIds": [
            "clay-index"
          ]
        }
      ],
      "sourceIds": [
        "clay-yang",
        "clay-index"
      ],
      "reviewedAt": "2026-10-27"
    },
    {
      "id": "poincare",
      "title": "Poincaré Conjecture",
      "fields": [
        "Math"
      ],
      "specialty": "Geometric topology",
      "diseases": [],
      "collection": "Millennium Prize Problems",
      "summary": "Characterize the three-dimensional sphere among closed, simply connected three-manifolds.",
      "origin": {
        "date": "1904",
        "precision": "year",
        "eventType": "formulated",
        "note": "Poincaré formulated the question in 1904.",
        "sourceIds": [
          "clay-poincare"
        ]
      },
      "historyEnd": {
        "date": "2003",
        "precision": "year",
        "eventType": "proposed_result",
        "note": "Endpoint: the final year of Perelman’s 2002–2003 preprints, not the later prize recognition.",
        "sourceIds": [
          "clay-poincare"
        ]
      },
      "status": {
        "state": "accepted",
        "authorityLabel": "Solved",
        "basis": "Clay Mathematics Institute classification, reviewed 2026-10-27.",
        "sourceIds": [
          "clay-poincare"
        ]
      },
      "milestones": [
        {
          "date": "2000-05-24",
          "precision": "day",
          "eventType": "named",
          "note": "Included in the Millennium Prize Problems; this is not the original formulation date.",
          "sourceIds": [
            "clay-index"
          ]
        },
        {
          "date": "2002",
          "precision": "year",
          "eventType": "proposed_result",
          "note": "Perelman began publishing the proof in preprints; work continued in 2003.",
          "sourceIds": [
            "clay-poincare"
          ]
        },
        {
          "date": "2010-03-18",
          "precision": "day",
          "eventType": "recognition",
          "note": "Clay announced the Millennium Prize recognition. Human solution by Grigoriy Perelman, building on Richard Hamilton’s Ricci flow.",
          "sourceIds": [
            "clay-poincare"
          ]
        }
      ],
      "sourceIds": [
        "clay-poincare",
        "clay-index"
      ],
      "reviewedAt": "2026-10-27"
    },
    {
      "id": "matrix",
      "title": "Efficient matrix multiplication",
      "fields": [
        "Computer Science",
        "Math"
      ],
      "specialty": "Algorithm design",
      "diseases": [],
      "collection": "Research frontiers",
      "summary": "Improve matrix multiplication algorithms while recording the exact field, dimensions, and operation count.",
      "origin": null,
      "historyEnd": null,
      "status": {
        "state": "open",
        "authorityLabel": "Open research area",
        "basis": "A scoped research contribution does not resolve this entire research area.",
        "sourceIds": [
          "alpha-paper",
          "alpha-blog"
        ]
      },
      "milestones": [],
      "sourceIds": [
        "alpha-paper",
        "alpha-blog"
      ],
      "reviewedAt": "2026-10-27"
    },
    {
      "id": "plasma",
      "title": "Reliable tokamak plasma control",
      "fields": [
        "Physics"
      ],
      "specialty": "Plasma physics",
      "diseases": [],
      "collection": "Research frontiers",
      "summary": "Control plasma configurations under experimental and operational constraints. This is one part of fusion research.",
      "origin": null,
      "historyEnd": null,
      "status": {
        "state": "open",
        "authorityLabel": "Open research area",
        "basis": "A scoped research contribution does not resolve this entire research area.",
        "sourceIds": [
          "tcv-paper"
        ]
      },
      "milestones": [],
      "sourceIds": [
        "tcv-paper"
      ],
      "reviewedAt": "2026-10-27"
    },
    {
      "id": "ipf",
      "title": "Treating idiopathic pulmonary fibrosis",
      "fields": [
        "Medicine"
      ],
      "specialty": "Pulmonology",
      "diseases": [
        "Idiopathic pulmonary fibrosis"
      ],
      "collection": "Research frontiers",
      "summary": "Develop and validate treatments for IPF, tracking population, endpoints, safety, and clinical phase separately.",
      "origin": null,
      "historyEnd": null,
      "status": {
        "state": "open",
        "authorityLabel": "Open research area",
        "basis": "A scoped research contribution does not resolve this entire research area.",
        "sourceIds": [
          "ipf-paper"
        ]
      },
      "milestones": [],
      "sourceIds": [
        "ipf-paper"
      ],
      "reviewedAt": "2026-10-27"
    }
  ],
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      "id": "alphaevolve-matrix",
      "problemId": "matrix",
      "title": "48 multiplications for a 4 × 4 construction",
      "reportedAt": "2025-05-14",
      "stage": "proposed_result",
      "scope": "Reported a construction for multiplying two 4 × 4 complex-valued matrices using 48 scalar multiplications.",
      "limitations": "Does not establish global optimality, resolve P vs NP, or supply a measured end-to-end mission duration.",
      "models": [
        {
          "name": "AlphaEvolve (Gemini-powered)",
          "immutableVersion": null,
          "role": "Research contribution",
          "sourceIds": [
            "alpha-blog",
            "alpha-paper"
          ]
        }
      ],
      "humanContributions": "Researchers designed the search objective, evaluation framework, and experimental analysis.",
      "mission": {
        "startedAt": null,
        "endedAt": null,
        "wallSeconds": {
          "value": null,
          "unit": "seconds",
          "measurement": "unknown",
          "boundary": "Documented mission assignment to scoped outcome; not publication-to-publication time.",
          "sourceIds": []
        },
        "computeHours": {
          "value": null,
          "unit": "accelerator_hours",
          "measurement": "unknown",
          "boundary": "All runs including failed attempts and retries.",
          "sourceIds": []
        },
        "humanHours": {
          "value": null,
          "unit": "person_hours",
          "measurement": "unknown",
          "boundary": "Design, review, engineering, and validation.",
          "sourceIds": []
        },
        "timingSourceIds": []
      },
      "resources": {
        "hardware": {
          "value": null,
          "unit": "USD",
          "measurement": "unknown",
          "boundary": "Allocated hardware cost; purchase price is not charged entirely to one run.",
          "sourceIds": []
        },
        "training": {
          "value": null,
          "unit": "USD",
          "measurement": "unknown",
          "boundary": "Training allocation separate from inference.",
          "sourceIds": []
        },
        "inference": {
          "value": null,
          "unit": "USD",
          "measurement": "unknown",
          "boundary": "Inference including search and failed attempts.",
          "sourceIds": []
        },
        "retries": {
          "value": null,
          "unit": "USD",
          "measurement": "unknown",
          "boundary": "Retry cost; avoid double counting with inference.",
          "sourceIds": []
        },
        "people": {
          "value": null,
          "unit": "USD",
          "measurement": "unknown",
          "boundary": "Research, engineering, review, and operations.",
          "sourceIds": []
        },
        "experimentalValidation": {
          "value": null,
          "unit": "USD",
          "measurement": "unknown",
          "boundary": "Physical experiments, clinical trials, or independent validation.",
          "sourceIds": []
        },
        "energy": {
          "value": null,
          "unit": "kWh",
          "measurement": "unknown",
          "boundary": "Training, inference, hardware and facility boundaries require disclosure.",
          "sourceIds": []
        },
        "total": {
          "value": null,
          "unit": "USD",
          "measurement": "unknown",
          "boundary": "No total until inclusion, exclusions, currency basis and overlap are documented.",
          "sourceIds": []
        }
      },
      "evidence": {
        "artifact": {
          "state": "documented",
          "note": "The versioned research paper describes the construction. Independent execution has not been performed by this catalog.",
          "sourceIds": [
            "alpha-paper"
          ]
        },
        "peerReview": {
          "state": "not_assessed",
          "note": "Not established by this catalog review.",
          "sourceIds": []
        },
        "independentReproduction": {
          "state": "not_assessed",
          "note": "Not established by this catalog review.",
          "sourceIds": []
        },
        "formalVerification": {
          "state": "not_assessed",
          "note": "Not established by this catalog review.",
          "sourceIds": []
        },
        "regulatoryApproval": {
          "state": "not_assessed",
          "note": "Not established by this catalog review.",
          "sourceIds": []
        },
        "practicalDeployment": {
          "state": "not_assessed",
          "note": "Not established by this catalog review.",
          "sourceIds": []
        }
      },
      "clinical": null,
      "events": [
        {
          "date": "2025-05-14",
          "stage": "proposed_result",
          "note": "Publication of the scoped result; not a measured mission endpoint.",
          "sourceIds": [
            "alpha-blog",
            "alpha-paper"
          ]
        }
      ],
      "sourceIds": [
        "alpha-blog",
        "alpha-paper"
      ],
      "reviewedAt": "2026-10-27",
      "formalProof": null
    },
    {
      "id": "tcv-control",
      "problemId": "plasma",
      "title": "Reinforcement learning on TCV",
      "reportedAt": "2022-02-16",
      "stage": "verification",
      "scope": "A learned controller shaped and maintained several plasma configurations on the TCV experimental tokamak.",
      "limitations": "A control experiment does not establish commercial fusion, net electric power, or deployment across reactors.",
      "models": [
        {
          "name": "Deep reinforcement learning controller",
          "immutableVersion": null,
          "role": "Research contribution",
          "sourceIds": [
            "tcv-paper"
          ]
        }
      ],
      "humanContributions": "Researchers developed the simulator and control objectives and operated and evaluated the TCV experiments.",
      "mission": {
        "startedAt": null,
        "endedAt": null,
        "wallSeconds": {
          "value": null,
          "unit": "seconds",
          "measurement": "unknown",
          "boundary": "Documented mission assignment to scoped outcome; not publication-to-publication time.",
          "sourceIds": []
        },
        "computeHours": {
          "value": null,
          "unit": "accelerator_hours",
          "measurement": "unknown",
          "boundary": "All runs including failed attempts and retries.",
          "sourceIds": []
        },
        "humanHours": {
          "value": null,
          "unit": "person_hours",
          "measurement": "unknown",
          "boundary": "Design, review, engineering, and validation.",
          "sourceIds": []
        },
        "timingSourceIds": []
      },
      "resources": {
        "hardware": {
          "value": null,
          "unit": "USD",
          "measurement": "unknown",
          "boundary": "Allocated hardware cost; purchase price is not charged entirely to one run.",
          "sourceIds": []
        },
        "training": {
          "value": null,
          "unit": "USD",
          "measurement": "unknown",
          "boundary": "Training allocation separate from inference.",
          "sourceIds": []
        },
        "inference": {
          "value": null,
          "unit": "USD",
          "measurement": "unknown",
          "boundary": "Inference including search and failed attempts.",
          "sourceIds": []
        },
        "retries": {
          "value": null,
          "unit": "USD",
          "measurement": "unknown",
          "boundary": "Retry cost; avoid double counting with inference.",
          "sourceIds": []
        },
        "people": {
          "value": null,
          "unit": "USD",
          "measurement": "unknown",
          "boundary": "Research, engineering, review, and operations.",
          "sourceIds": []
        },
        "experimentalValidation": {
          "value": null,
          "unit": "USD",
          "measurement": "unknown",
          "boundary": "Physical experiments, clinical trials, or independent validation.",
          "sourceIds": []
        },
        "energy": {
          "value": null,
          "unit": "kWh",
          "measurement": "unknown",
          "boundary": "Training, inference, hardware and facility boundaries require disclosure.",
          "sourceIds": []
        },
        "total": {
          "value": null,
          "unit": "USD",
          "measurement": "unknown",
          "boundary": "No total until inclusion, exclusions, currency basis and overlap are documented.",
          "sourceIds": []
        }
      },
      "evidence": {
        "artifact": {
          "state": "not_assessed",
          "note": "Not established by this catalog review.",
          "sourceIds": []
        },
        "peerReview": {
          "state": "documented",
          "note": "Published research article; peer review is separate from independent reproduction.",
          "sourceIds": [
            "tcv-paper"
          ]
        },
        "independentReproduction": {
          "state": "not_assessed",
          "note": "Not established by this catalog review.",
          "sourceIds": []
        },
        "formalVerification": {
          "state": "not_assessed",
          "note": "Not established by this catalog review.",
          "sourceIds": []
        },
        "regulatoryApproval": {
          "state": "not_assessed",
          "note": "Not established by this catalog review.",
          "sourceIds": []
        },
        "practicalDeployment": {
          "state": "limited",
          "note": "Experimental deployment on TCV only.",
          "sourceIds": [
            "tcv-paper"
          ]
        }
      },
      "clinical": null,
      "events": [
        {
          "date": "2022-02-16",
          "stage": "verification",
          "note": "Publication of the scoped result; not a measured mission endpoint.",
          "sourceIds": [
            "tcv-paper"
          ]
        }
      ],
      "sourceIds": [
        "tcv-paper"
      ],
      "reviewedAt": "2026-10-27",
      "formalProof": null
    },
    {
      "id": "rentosertib-phase2a",
      "problemId": "ipf",
      "title": "Rentosertib: phase 2a evidence",
      "reportedAt": "2025-06-03",
      "stage": "verification",
      "scope": "A randomized, double-blind, placebo-controlled phase 2a study enrolled 71 patients with IPF for 12 weeks.",
      "limitations": "Historical early trial evidence, not proof of a cure or a current approval claim. Larger, longer studies are needed; the catalog has not assessed current regulatory status.",
      "models": [
        {
          "name": "Generative AI drug-discovery systems",
          "immutableVersion": null,
          "role": "Research contribution",
          "sourceIds": [
            "ipf-paper"
          ]
        }
      ],
      "humanContributions": "Scientists selected and tested the target and compound; clinical teams designed, conducted, and analyzed the trial.",
      "mission": {
        "startedAt": null,
        "endedAt": null,
        "wallSeconds": {
          "value": null,
          "unit": "seconds",
          "measurement": "unknown",
          "boundary": "Documented mission assignment to scoped outcome; not publication-to-publication time.",
          "sourceIds": []
        },
        "computeHours": {
          "value": null,
          "unit": "accelerator_hours",
          "measurement": "unknown",
          "boundary": "All runs including failed attempts and retries.",
          "sourceIds": []
        },
        "humanHours": {
          "value": null,
          "unit": "person_hours",
          "measurement": "unknown",
          "boundary": "Design, review, engineering, and validation.",
          "sourceIds": []
        },
        "timingSourceIds": []
      },
      "resources": {
        "hardware": {
          "value": null,
          "unit": "USD",
          "measurement": "unknown",
          "boundary": "Allocated hardware cost; purchase price is not charged entirely to one run.",
          "sourceIds": []
        },
        "training": {
          "value": null,
          "unit": "USD",
          "measurement": "unknown",
          "boundary": "Training allocation separate from inference.",
          "sourceIds": []
        },
        "inference": {
          "value": null,
          "unit": "USD",
          "measurement": "unknown",
          "boundary": "Inference including search and failed attempts.",
          "sourceIds": []
        },
        "retries": {
          "value": null,
          "unit": "USD",
          "measurement": "unknown",
          "boundary": "Retry cost; avoid double counting with inference.",
          "sourceIds": []
        },
        "people": {
          "value": null,
          "unit": "USD",
          "measurement": "unknown",
          "boundary": "Research, engineering, review, and operations.",
          "sourceIds": []
        },
        "experimentalValidation": {
          "value": null,
          "unit": "USD",
          "measurement": "unknown",
          "boundary": "Physical experiments, clinical trials, or independent validation.",
          "sourceIds": []
        },
        "energy": {
          "value": null,
          "unit": "kWh",
          "measurement": "unknown",
          "boundary": "Training, inference, hardware and facility boundaries require disclosure.",
          "sourceIds": []
        },
        "total": {
          "value": null,
          "unit": "USD",
          "measurement": "unknown",
          "boundary": "No total until inclusion, exclusions, currency basis and overlap are documented.",
          "sourceIds": []
        }
      },
      "evidence": {
        "artifact": {
          "state": "not_assessed",
          "note": "Not established by this catalog review.",
          "sourceIds": []
        },
        "peerReview": {
          "state": "documented",
          "note": "Published research article; peer review is separate from independent reproduction.",
          "sourceIds": [
            "ipf-paper"
          ]
        },
        "independentReproduction": {
          "state": "not_assessed",
          "note": "Not established by this catalog review.",
          "sourceIds": []
        },
        "formalVerification": {
          "state": "not_assessed",
          "note": "Not established by this catalog review.",
          "sourceIds": []
        },
        "regulatoryApproval": {
          "state": "not_assessed",
          "note": "Not established by this catalog review.",
          "sourceIds": []
        },
        "practicalDeployment": {
          "state": "not_assessed",
          "note": "Not established by this catalog review.",
          "sourceIds": []
        }
      },
      "clinical": {
        "condition": "Idiopathic pulmonary fibrosis",
        "population": "71 patients with IPF in the reported trial",
        "phase": "2a",
        "durationWeeks": 12,
        "primaryEndpoint": "Percentage of patients experiencing at least one treatment-emergent adverse event",
        "secondaryEndpoints": [
          "Forced vital capacity and other lung function measures"
        ],
        "registryId": "NCT05938920",
        "registryUrl": "https://clinicaltrials.gov/study/NCT05938920",
        "approvalStatus": "not_assessed",
        "sourceIds": [
          "ipf-paper"
        ]
      },
      "events": [
        {
          "date": "2025-06-03",
          "stage": "verification",
          "note": "Publication of the scoped result; not a measured mission endpoint.",
          "sourceIds": [
            "ipf-paper"
          ]
        }
      ],
      "sourceIds": [
        "ipf-paper"
      ],
      "reviewedAt": "2026-10-27",
      "formalProof": null
    }
  ],
  "forecasts": []
}